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It can, for instance, detect the omicron variation, which has lots of mutations in the area of the genome that encodes the so-called spike protein. Though tests based upon PCR or polymerase domino effect are highly precise, a key restriction is that PCR tests need dozens of cycles of heating and cooling to identify genetic product in a sample.

"This test runs at a continuous temperature level, so it removes the time to heat and cool and offers lead to about 30 minutes," said Lutz. Lutz and two coworkers spun out a brand-new company from the UW, Anavasi Diagnostics, which last year was supported by $300,000 from WE-REACH and later on got $14.

A detailed workflow for the Consistency COVID-19 test set.  Key Reference  et al. 2021 Initially, Lutz and his group hope the kits could be offered first for use in centers, as well as other settings with medical oversight, such as work environments and schools. Later, they want to adjust the test for home usage.

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"From the first day, we designed our test to be manufacturable at low expense and high volume, while providing fast results with PCR-like efficiency." The NIH funding will support high-volume production at a brand-new Anavasi facility near Seattle. "We plan to make our test available and budget-friendly throughout the world," said Lutz.

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Second author is Enos Kline, a UW research scientist in bioengineering, who initiated the job in early 2020. Co-authors in the Department of Bioengineering are doctoral trainees Robert Atkinson, Ian Hull, Qin Wang, and Shane Gilligan-Steinberg; research study researchers Michael Roller, Jack Henry Kotnik, Crissa Bennett and Daniel Leon; and doctoral alum Amy Oreskovic.

Cohen Endowed Professor in Family Medicine; Peter Han in the Department of Genome Sciences; Lea Starita, an assistant teacher of genome sciences; and Paul Drain, an associate professor of worldwide health, of medicine and of public health. The research was moneyed by the Seattle Flu Study and the National Institutes of Health.

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Tag(s): Barry Lutz College of Engineering COVID-19 COVID-19 studies Department of Bioengineering School of Medicine.